In ( f , i and j ) significance tested by two-sided Mann-Whitney
Voici une liste non-exhaustive des nombreuses fonctions importantes du glutathion : La fabrication de l'ADN, l'lment constitutif des protines et des cellules Le soutien de la fonction immunitaire La formation des spermatozodes La dgradation de certains radicaux libres Laide au fonctionnement de certaines enzymes La rgnration des vitamines C et E Llimination de mtaux lourds Faciliter le traitement des graisses par le foie et la vsicule biliaire La lutte contre l'apoptose (ou mort cellulaire programme) Le glutathion, l'un des nutriments de dfense intracellulaire les plus puissants, est prsent en particulier dans les cellules trs sensibles la toxicit comme le cerveau, les reins, le foie, le cur, les poumons, la peau, l'pithlium intestinal, la corne et la rtine
J Pharm Pharmacol 76(8):10181027 Lu X et al (2021) MiR-27a-3p promotes non-small cell lung cancer through SLC7A11-mediated-ferroptosis
While the role of NRF-2 has been proven in hepatic pathogenesis and it has been established as a potential therapeutic target, it is at present under worldwide researches.AbbreviationsAMPK-PGC-1 Activated protein kinase coactivator 1 alpha ARE antioxidant response element CLD chronic liver disease CYP cytochromes GST glutathione S transferase GSH glutathione HFD high fat diet HO-1 heme oxygenase 1 iNOS inducible form of nitric-oxid Synthase JAK2 janus kinasa 2 KEAP1 Kelch-like ECH associating protein-1 PTEN liver specific phosphatase and tensin homology UPRmt mitochondrial unfolded protein Response NAFLD nonalcoholic fatty liver disease NASH nonalcoholic steatohepatitis NRF-2 nuclear factor (erythroid-derived 2)-like 2 PGC-1a peroxisome proliferator-activated PTENLKO PTEN deletion mice RNS reactive nitrogen species ROS reactive oxygen species STAT5 signal transducer and activator of transcription 5 SIRT-1 sirtuine 1 SREBP-1 sterol regulatory element-binding protein-1 TRX thioredoxin-dependent enzymes UPR unfolded protein response Conflict of interest The authors have no conflicts of interest to declare whatsoever
